Words a bioinformatician never wants to hear

• July 6, 2012 • Comments (28)

Something cynical for a rainy Friday at the end of a long week :^)

  • “The data is all in these [proprietary and undocumented format] files.”
  • “What I want is a program to browse, edit and validate gigabyte-size whole genome sequencing runs. It should import and export all known formats. And it has to run in a browser. And some of staff refuse to use anything but IE6.”
  • (After delivering an insignificant or negative result) “Can’t you analyse it again?”
  • “Why don’t we put the new server rack in your office?”
  • “That software you wrote is buggy! [What happened?] It’s not working! [How do you know that?] It’s broken! [In what way?] Can’t you just fix it? [How? I don't know what's wrong ...]
  • “I don’t understand: [large research institute / multinational commercial company] has software that can do this. Can’t you write something similar?”
  • “This is a great / exciting opportunity …”
  • “This program is great. But could you rewrite it in another programming language?”
  • “That database and web service you wrote for X? We need one that works just like that. Except for … [lists dozens of ways in which the new service actually differs entirely from the previous one]
  • “You want to know what feature or task is the most important? They all are!”
  • (After being told that the data sample is too small, or incorrectly sampled such that analysis is impossible.) “You don’t understand – we really need this result.”
  • “Here’s the data. I haven’t had time to clean it up, so it might be incomplete. And some of the identifiers might not agree. And there are mis-spellings …”
  • (After delivering the outcome of an analysis) “Pth – that result is obvious.”
  • “Don’t worry about who’s going to [maintain the new database / monitor the new service / curate the data / come in on the weekends to restart the system]. We’ll work that out later …”
  • “So X wrote us this pipeline before he left. I’m not sure if he finished it. No, there’s no documentation. Can you get it working? By next week?”
  • “I think I read a way to do this: it was in a journal, maybe. Or on a webpage. Done by some lab in France. Or was it China? Anyway, it should be simple.”
  • “Do you really need that much disk space for this NGS data?”
  • “So your program crashed when I tried to load data. What format? Does that matter? They were Word documents. Really, the program doesn’t read those?”
  • “So, what you’re saying is that a Word document isn’t a text file. But I used Courier as a font.”
  • “We need this program. It’s really simple … [30 minutes of essential features follow]
  • (While waiting for the result of a Bayesian calculation) “Why does it take so long to get this answer? Can’t you just make it go faster?”
  • “I know you said that 30 data points were the minimum for statistical rigour. But we only got 5. Can’t you analyze it anyway?”
  • “We keep all those records in Excel files … uh, I think this is the most current version …”
  • “The Z lab showed you could do this [with 10 genes and a computing cluster]. So do you think you could this this with our data [200 whole genomes, on a PC]?”
  • “Good news – we got a huge grant for sequencing and annotating 6 squillion whole genomes. You’re not on the grant and we didn’t budget for any bioinformatic work but here’s the data. Can you have this done by next week?”
  • (After being told that an analysis is impossible or ill-considered) “But X over in Y’s lab does it all the time.”
  • “Uh, so what is it that you’re doing again?”

 

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About the Author

Originally a laboratory scientist, PM stumbled into the world of computational biology in the dark days when Perl, CGI and C++ were tools of choice. Since then, he has lived and worked in Australia, South Africa and the UK on topics ranging from macroevolution through phylogenetics to computational embryology. Currently he works for the Health Protection Agency (UK), chasing and tracing pathogens and their evolution.

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  • RadhouaneANIBA

    :D yeah some sounds familiar :D

  • http://www.facebook.com/profile.php?id=873755108 Moonfleet Eldai

    Convince us that bioinformatics can help my lab, I don’t see a necessity (a lab technologist once told me)

    • Paul-Michael Agapow

      Why, what do you do?

      • Paul-Michael Agapow

        Ah – that was said to _you_. That smarts.

        • http://www.facebook.com/profile.php?id=873755108 Moonfleet Eldai

          Two weeks ago and I still keep coming to reflect on this article. It is such a pain to see that many of the points apply where I work, and when we say we don’t have the infrastructure to do that analysis or that this data size is small they go right off to the CEO and complain that “These bioinformaticians don’t know how to get the job done !”

          • Paul-Michael Agapow

            That happens to you too. Ouch. (Sure – methodological limitations are _my_ fault …)

    • http://www.facebook.com/razumovs Jane Razumovski

      Of course bioinformaticians are unnecessary!  the aforementioned lab technologist can do all of this himself.  By hand, in the lab notebook.  In 10+ years.

      • http://twitter.com/srynearson1 srynearson

        +2 extra years using excel (6 months alone for all the times it crashes). 

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  • JMH1954

    “The critical information in this Excel file is encoded in the conditional formatting”

  • vldrrm

     Always thought a sole role of IE in M$ Win is to download some browser software….

  • Matt Hudson

    “Because you only did the data analysis, we decided you didn’t need to be an author on the paper”

    • RadhouaneANIBA

      Good One :D

    • Paul-Michael Agapow

      Oh dear god, yes. That’s a classic.

    • Paul T Morrison

      You have polite researchers who actually tell you that you aren’t going to be an author? It’s much more fun to just wait until publication to see the non-author, non-acknowledgement. 

      How about, “But if I made you an author everyone would think you did all the work.” Now that’s honesty. ;-O

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  • http://www.facebook.com/profile.php?id=1514545115 Emmanuel Boutet

    What about: well you did it in python 2.6 (within 2 years), but it’s time to go to python 3.0 for futur compatibility. Can you adapt all your scripts by next week to make it compatible with X ?!? (the same apply to QT, Perl or what ever….)

  • Victor Jongeneel

    “Could I spend a day with your group so that I can learn to analyze my data myself?” (actual quote heard a few days ago…)

    • http://www.facebook.com/debasish.mukherjee.923 Debasish Mukherjee

      Its really true for me also…

  • Sujan mamidi

    the words someone asked me “is there some other analysis to say that locus A is significant (even though it is not even at 75 CI or not predicted/estimated in previous literature) , because I know that locus is significant” .

    Is there any journal that publishes just views based on no scientific evidence that I can forward him ;)

  • Michael Moorhouse

    “We did the analysis ourselves, so you are not on the paper.”
    [But how?  And can you justify it?  Even your extended methods section simply says 'aligned to the set of allelic reference sequences' or something similar]

  • krishna mohan

    Probably I need to add another one- 
    (Suppose a program takes one day to run)  Why dont we make a quick and dirty analysis that could finish in one hr and we could see the results?! smart way isnt it ?

  • krishna mohan

    Oh this molecular simulation might take a month. Can we do something smart ? We could take a few hundred atoms randomly and do a simple simulation to see if it works! smart isn’t it !

  • http://twitter.com/fabiomarroni Fabio Marroni

    Really happened, on “broken” software:
    Your software doesn’t work! [What happened?] It’s broken! [What's the error message?] Cannot open file ABC. [file name was XYZ, or even worse A B C (with spaces!)]

  • Thomas Triplet

    Damn, that’s really depressing…

    Heard myself: The editor of journal X asked us to update our obsolete package. Can you do it so that we can publish it again. huh? Of course you won’t be on the paper, it’s just an update.

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  • http://twitter.com/DataDiviner Alexander Frieden

    Holy crap Paul, this cracked me up

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